| 摘要 |
2-Cyclopropylhydrocarbylamino-pyrrolidine derivatives (I) are new. 2-Cyclopropylhydrocarbylamino-pyrrolidine derivatives of formula (I) and their isomers and salts are new: n = 1 or 2; X = 1-6C alkylene, 2-6C alkenylene (containing 1-3 double bonds), 2-6C alkynylene (containing 1-3 triple bonds) or optionally Q-substituted arylene or heteroarylene; R10, R12 = H or 1-6C alkyl; R11 = H; or R10+R11 or R11+R12 = a bond; R2-R4 = H, 1-6C alkyl, 1-6C hydroxyalkyl, 1-6C alkoxy, 2-7C alkoxycarbonyl or optionally Q-substituted aryl, aryl(1-6C)alkyl or aryloxy(1-6C)alkyl, or two of R2-R4 form a 5-7C cycloalkane ring; Q = halogen, 1-6C alkyl, 1-6C alkoxy, OH, CN, NO2, NH2 and/or mono- or di(1-6C alkyl)amino; aryl = phenyl or naphthyl; arylene = phenylene or naphthylene; and heteroaryl and heteroarylene = 4- to 11-membered mono- or bicyclic saturated or partially unsaturated groups containing 1-5 heteroatoms selected from N, O and S. An Independent claim is also included for a process for preparing compounds (I). |
