发明名称 Protein kinase regulation
摘要 A method of identifying a compound that modulates the protein kinase activity of a protein kinase having a hydrophobic pocket in the position equivalent to the hydrophobic pocket of Protein Kinase A (PKA) that is defined by residues including Lys76, Leu116, Val80 and/or Lys111 of full-length mouse PKA, wherein the ability of the compound to inhibit, promote or mimic the interaction of the said hydrophobic pocket-containing protein kinase with an interacting polypeptide is measured and a compound that inhibits, promotes or mimics the said interaction interacts is selected, wherein the interacting polypeptide with the hydrophobic pocket of the protein kinase and/or comprises the amino acid sequence Phe/Tyr-Xaa-Xaa-Phe/Tyr.
申请公布号 AU2187301(A) 申请公布日期 2001.06.25
申请号 AU20010021873 申请日期 2000.12.04
申请人 UNIVERSITY OF DUNDEE THE 发明人 DARIO ALESSI;RICARDO BIONDI
分类号 G01N33/50;A61K38/00;A61K45/00;A61K48/00;A61P3/10;A61P9/10;A61P35/00;C07K14/00;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/12;C12N9/96;C12N15/09;C12Q1/48;G01N33/15;G01N33/543 主分类号 G01N33/50
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