PROCESSES FOR PREPARING CLARITHROMYCIN POLYMORPHS AND NOVEL POLYMORPH IV
摘要
The present invention relates to processes for converting clarithromycin Form 0 to clarithromycin Form II, which include slurrying clarithromycin the Form 0 in water. The present invention also relates to processes for the preparation of clarithromycin Form II by converting erythromycin A to clarithromycin and thereafter converting clarithromycin Form 0 to clarithromycin Form II by slurrying. The present invention further relates to the novel clarithromycin polymorph Form IV, a process for its preparation, pharmaceutical compositions comprising the compound, and methods of using the compound as a therapeutic agent.
申请公布号
WO0144262(A1)
申请公布日期
2001.06.21
申请号
WO2000US33845
申请日期
2000.12.15
申请人
TEVA PHARMACEUTICAL INDUSTRIES LTD.;TEVA PHARMACEUTICALS USA, INC.;AVRUTOV, ILYA;LIFSHITZ, IGOR;BOROCHOVITZ, RONEN;MASARWA, BASEM;SCHWARTZ, EDI
发明人
AVRUTOV, ILYA;LIFSHITZ, IGOR;BOROCHOVITZ, RONEN;MASARWA, BASEM;SCHWARTZ, EDI