发明名称 |
PROCESS FOR THE PREPARATION OF TRANS-3-ALKYLOXY-4-HYDROXYTETRAHYDROFURAN |
摘要 |
Disclosed is a process for preparIng novel <i>trans</i>-3-alkyloxy-4-hydroxytetrahydrofurans including racemic and substantially enantiomerically pure (3S,4S)-<i>trans</i>-3-alk(en)yloxy-4-hydroxytetrahydrofurans and (3R,4R)-<i>trans</i>-3-alk(en)yloxy-4-acyloxytetrahydrofurans. The disclosed process comprises the steps of reacting 3,4-epoxytetrahydrofuran with an alcohol under Lewis acid catalysis to obtain a racemic <i>trans</i>-3-alk(en)yloxy-4-hydroxytetrahydrofuran; contacting the <i>trans</i>-3-alk(en)yloxy-4hydroxy-tetrahydrofuran with an acyl donor in the presence of a hydrolase enzyme to produce a mixture of a substantially enantiomerically pure (3S,4S)-<i>trans</i>-3-alk(en)yloxy-4-hydroxytetrahydrofuran and a substantially enantiomerically pure (3R,4R)-<i>trans</i>-3-alk(en)yloxy-4-acyloxytetrahydrofuran; and separating the components of the mixture by partitioning between water and a solvent immiscible with water.
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申请公布号 |
WO0144222(A1) |
申请公布日期 |
2001.06.21 |
申请号 |
WO2000US33710 |
申请日期 |
2000.12.13 |
申请人 |
EASTMAN CHEMICAL COMPANY |
发明人 |
BAYSTON, DANIEL, JOHN;CASSON, SHARON;LOVELL, JAMES, MATTHEW;SCOTT, RONALD, MICHAEL |
分类号 |
C07D307/20;C12P17/04;(IPC1-7):C07D307/60 |
主分类号 |
C07D307/20 |
代理机构 |
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代理人 |
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主权项 |
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