发明名称 |
SUBSTITUTED 1,2,3-TRIAZOLO[1,5-A]QUINAZOLINES FOR ENHANCING COGNITION |
摘要 |
The present invention provides a compound of formula (I) in which R1 is generally hydrogen or CF3, R2 is generally hydrogen, W is a cyclic amine, a heterocycle or a group L-Y-X where L-Y is a linking portion and X is general ly an aromatic or non-aromatic heterocycle, alkyl or alkylcarbonyl and Z is generally a heterocycle such as 5-methylisoxazol-3-yl, and pharmaceutically acceptable salts thereof for enhancing cognition in conditions such as Alzheimer's Disease, pharmaceutical compositions comprising them, their use for manufacturing medicaments and methods of treatment using them.
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申请公布号 |
CA2392955(A1) |
申请公布日期 |
2001.06.21 |
申请号 |
CA20002392955 |
申请日期 |
2000.12.11 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
CHAMBERS, MARK STUART;MACLEOD, ANGUS MURRAY;MAXEY, ROBERT JAMES;JONES, PHILIP;BRYANT, HELEN JANE |
分类号 |
A61K31/519;A61K31/5375;A61K31/54;A61K31/5513;A61P25/28;C07D487/04;C07D519/00;(IPC1-7):C07D487/04;A61K31/505 |
主分类号 |
A61K31/519 |
代理机构 |
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