OXADIAZOLE DERIVATIVES AND DRUGS CONTAINING THESE DERIVATIVES AS THE ACTIVE INGREDIENT

摘要

Oxadiazole derivatives represented by general formula (I) and nontoxic salts thereof, wherein R represents hydrogen, alkyl, CycA, etc.; AA1 represents a single bond, an amino acid residue, etc.; AA2 represents a single bond, an amino acid residue, etc.; R?7 and R8¿ represent each hydrogen, alkyl, etc.; R9 represents hydrogen or alkyl; and R10 represents hydrogen, alkyl, etc. Because of having a cysteine protease inhibitory activity, the compounds of general formula (I) are useful as preventives and/or remedies for inflammatory diseases, diseases induced by apoptosis, diseases induced in immune response failure, autoimmune diseases, diseases induced by the degradation of biological constituting proteins, shock, circulatory disorder, blood coagulation system disorder, malignant tumor, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitosis, neurodegenerative diseases, lung disorder, bone resorption diseases, endocrine hyperenergia diseases, etc.