METHODS OF DIAGNOSIS AND TREATMENT BY BINDING P75/AIRM1
摘要
p75/AIRM1 is expressed on myeloid cells at stages of differentiation and determination of its presence is useful in monitoring cellular proliferation and determining proliferative states of cells, especially myeloid cells in diseases such as chronic myeloid leukemia. Ligands such as antibody molecules, for instance the QA79 monoclonal antibody deposited under accession number ICLC No. PD99003, are useful for methods of diagnosis and treatment, e.g. by way of inhibition of cellular proliferation and induction of apoptosis in cells.
申请公布号
WO0144808(A2)
申请公布日期
2001.06.21
申请号
WO2000EP12509
申请日期
2000.12.11
申请人
UNIVERSITA DEGLI STUDI DI GENOVA, DIPARTIMENTO DI;BIASSONI, ROBERTO;MORETTA, ALESSANDRO;MORETTA, LORENZO;MINGARI, MARIA, CRISTINA