发明名称 |
METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OFATHEROSCLEROSIS, RESTENOSIS AND RELATED DISORDERS |
摘要 |
Methods and compositions for the prevention and treatment of all forms of atherosclerosis are described. Administration of compounds such as thalidomide, its analogs, hydrolysis products, metabolites, derivatives and precursors as well as additional compounds capable of inhibiting tumor necrosis factor .alpha. (TNF-.alpha.) are used in the invention. Also disclosed is the coating of prosthetic devices, such as stents, with the compounds of the invention for the prevention and/or treatment of restenosis .
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申请公布号 |
CA2395474(A1) |
申请公布日期 |
2001.06.21 |
申请号 |
CA20002395474 |
申请日期 |
2000.12.13 |
申请人 |
CELGENE CORPORATION;CELGENE CORP.;CELGENE CORPORATION |
发明人 |
ZELDIS, JEROME B. |
分类号 |
C07D491/044;A61F2/84;A61K9/00;A61K31/16;A61K31/165;A61K31/195;A61K31/4035;A61K31/44;A61K31/445;A61K31/454;A61K45/00;A61L27/00;A61L29/00;A61L31/00;A61L33/00;A61P3/04;A61P3/06;A61P3/10;A61P9/08;A61P9/10;A61P9/12;A61P31/10;A61P43/00;C07D209/46;C07D209/48;C07D401/04;(IPC1-7):A61K31/445 |
主分类号 |
C07D491/044 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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