NOVEL PROCESSES FOR MAKING- AND A NEW CRYSTALLINE FORM OF- LEFLUNOMIDE
摘要
New leflunomide Form III is disclosed, along with processes for preparing it. The present invention also provides an economic process for preparing leflunomide Form II and a process for preparing leflunomide Form I from leflunomide Form III. Pharmaceutical compositions and dosage forms containing the new form and methods of using them for the treatment of rheumatoid arthritis are also disclosed.
申请公布号
WO0143742(A1)
申请公布日期
2001.06.21
申请号
WO2000US33866
申请日期
2000.12.14
申请人
TEVA PHARMACEUTICALS INDUSTRIES LTD.;TEVA PHARMACEUTICALS USA, INC.;AVRUTOV, ILYA;GERSHON, NEOMI;ARONHIME, JUDITH