发明名称 |
Improved polyamides for binding in the minor groove of double stranded DNA |
摘要 |
<p>The invention encompasses improved polyamides for binding to specific nucleotide sequences in the minor groove of double stranded DNA. The 3-hydroxy-N-methylpyrrole/N-methylpyrrole carboxamide pair specifically recognizes the T.A base pair, while the N-methylpyrrole/3-hydroxy-N-methylpyrrole pair recognizes A.T nucleotide pairs. Similarly, an N-methylimidizole/N-methylpyrrole carboxamide pair specifically recognizes the G.C nucleotide pair, and the N-methylpyrrole/N-methylimidizole carboxamide pair recognizes the C.G nucleotide pair.</p> |
申请公布号 |
AU734715(B2) |
申请公布日期 |
2001.06.21 |
申请号 |
AU19980064334 |
申请日期 |
1998.01.21 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
ELDON E. BAIRD;PETER B. DERVAN |
分类号 |
A61K38/00;A61K31/40;A61K31/415;A61K31/4178;A61K31/785;A61K38/04;A61K47/48;A61K49/00;A61P43/00;C07D207/34;C07D233/90;C07D403/12;C07D403/14;C07K5/078;C07K7/02;C07K7/04;C08G69/00;C08G69/08;C12N15/09;C12Q1/68;(IPC1-7):C07D207/34 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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