METHOD OF SELECTION OF PATIENTS WITH HYPERTENSIA FOR TREATMENT WITH NEBIVOLOL

摘要

medicine, cardiology, pharmacy. SUBSTANCE: method involves assay of platelet guanylate cyclase activity stimulated with protoporphyrin IX. Monotherapy with nebivolol is prescribed if its activity is below 250 pmole/ /min/mg and nebivolol is combined with hydrochlorothiazide as an other antihypertension agent if enzyme activity is above 250 pmole/min/mg. Method provides differentiating effect on vasodilating function of endothelium tissue. EFFECT: decreased time for hypotensive effect attainment. 1 tbl, 2 ex