| 摘要 |
<p>A process for the preparation of 2-(4-ethoxyphenyl)-2-methyl propyl alcohol comprising the steps of acylating phenol to give phenyl isobutyrate; subjecting said phenyl isobutyrate to Fries rearrangement to give 4-hydroxyphenyl-α-methylethyl ketone; ethylating said 4-hydroxyphenyl-α-methylethyl ketone to give 4-ethoxyphenyl-α-methylethyl ketone; halogenating said 4-ethoxyphenyl-α-methylethyl ketone to give 4-ethoxyphenyl-α-halo-α-methylethyl ketone; converting said halo ketone to halo ketal, subjecting said ketal to rearrangement to obtain an intermediate and hydrolysing the said intermediate to obtain 2-(4-ethoxyphenyl)-2-methyl propionic acid; converting said 2-(4-ethoxyphenyl)-2-methyl propionic acid to 2-(4-ethoxyphenyl)-2-methyl propionic acid alkyl ester, and treating said alkyl ester with an alkali metal in the presence of an alcohol to give 2-(4-ethoxyphenyl)-2-methyl propyl alcohol.</p> |
