发明名称 Benzimidazoles having antithrombotic activity
摘要 The present invention relates to new benzimidazoles of general formulawhereinRa to Rc, A, Ar and B are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof the prodrugs, the derivatives thereof which contain a group which is negatively charged under physiological conditions, instead of a carboxy group, and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.The compounds of the above general formula I wherein Rc denotes a cyano group are valuable intermediates for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein Rc denotes one of the amidino groups mentioned in claim 1 which have valuable pharmacological properties, particularly an antithrombotic activity.
申请公布号 US6248770(B1) 申请公布日期 2001.06.19
申请号 US19990338970 申请日期 1999.06.24
申请人 BOEHRINGER INGELHEIM PHARMA KG 发明人 RIES UWE;KAUFFMANN IRIS;HAUEL NORBERT;PRIEPKE HENNING;NAR HERBERT;STASSEN JEAN MARIE;WIENEN WOLFGANG
分类号 C07D235/16;C07D235/26;C07D401/08;C07D401/12;C07D403/04;C07D403/06;C07D403/08;C07D521/00;(IPC1-7):A61K31/415;A61K31/395;C07D235/04;C07D461/06;C07D239/02 主分类号 C07D235/16
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