发明名称 |
Reagent and method for delivery of molecules into cells |
摘要 |
Disclosed is a carrier peptide and a conjugate comprising a carrier peptide and a target molecule and a method for delivery of the target molecule into a cell. The carrier peptide contains from 10-15 amino acids, having a core sequence of 3-5 hydrophobic amino acids flanked by flanking amino acid sequences. The core sequence comprises residues selected from proline and leucine such that there is at least one each of proline and leucine and is symmetrical about an amino acid or a bond. Also disclosed is a method for delivery of a target molecule into a cell and a method for measuring a cellular process. |
申请公布号 |
AU1718101(A) |
申请公布日期 |
2001.06.18 |
申请号 |
AU20010017181 |
申请日期 |
2000.12.04 |
申请人 |
AMERSHAM PHARMACIA BIOTECH UK LIMITED |
发明人 |
JEFFREY KENNETH HORTON;JOHN ANTHONY SMITH;MICHELLE LEIGH TEEAR;JONATHAN MARK KENDALL;NIGEL PAUL MICHAEL |
分类号 |
A61K47/48;A61K49/00;C07K7/08 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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