发明名称 |
Penicillin production using transgenic merodiploid strains |
摘要 |
The object of this invention is a procedure for obtaining a genetically altered merodiploid strain of Penicillium chrysogenum in which the activity of a regulating gene that controls penicillin biosynthesis has been altered, so that this strain is an overproducer of penicillin. This invention represents the first case in which the biosynthesis of a metabolite of industrial interest has been increased by the manipulation of a regulating gene, and therefore is a considerable novelty compared with the previously used technologies. |
申请公布号 |
AU1864601(A) |
申请公布日期 |
2001.06.18 |
申请号 |
AU20010018646 |
申请日期 |
2000.12.07 |
申请人 |
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS;UNIVERSITY OF SHEFFIELD;IMPERIAL COLLEGE OF SCIENCE AND MEDICINE |
发明人 |
TERESA SUAREZ GONZALEZ;GEOFFREY TURNER;HERBERT ARST;MIGUEL ANGEL PENALVA SOTO |
分类号 |
C07K14/385;C12N1/15;C12N15/80;C12P37/00 |
主分类号 |
C07K14/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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