PROCESS FOR PREPARATION OF 1-SUBSTITUTED 5-HYDROXYMETHYL IMIDAZOLE

摘要

PURPOSE: A process for preparing 1-substituted 5-hydroxymethylimidazole(formula 1) by replacement of 1-substituted 5-hydroxymethylimidazole-2-thiol in position 2 with hydrogen is provided. Thereby, the desired compound can be prepared more safely, rapidly and purely in higher yield than the conventional process. CONSTITUTION: The formula compound is prepared by the reaction of 1-substituted 5-hydroxymethylimidazole-2-thiol of formula 2 in a solvent in the presence of an oxidant selected from the group consisting of hydrogen peroxide, alkyl hydrogen peroxide and alkali hypochlorite and a transition metal catalyst. In the formula, R is alkyl, hydroxy alkyl, aryl or substituted or nonsubstituted arylmethyl or diarylmethyl.