发明名称 |
METHODS FOR PURIFICATION OF FACTOR VII ACTIVATING PROTEASE, PROENZYME THEREOF OR MIXTURE OF BOTH FORMS, BY AFFINITY CHROMATOGRAPHY |
摘要 |
PURPOSE: Provided are methods for purification of factor VII activating protease, its proenzyme or a mixture of both forms, by affinity chromatography, thereby treating symptoms of thrombosis complication. CONSTITUTION: The methods for purifying factor VII-activating protease and/or its precursor comprises using one or more: (a) affinity chromatography separations which involves adsorption on: (i) calcium phosphate/hydroxylapatite; (ii) a hydrophobic matrix; (iii) a chelating matrix; (iv) a matrix carrying heparin or a related substance; and/or (v) a matrix carrying antibodies or their Fab/Fab2 fragments specific for factor VII-activating protease; and/or (b) fractional precipitations.
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申请公布号 |
KR20010049991(A) |
申请公布日期 |
2001.06.15 |
申请号 |
KR20000045204 |
申请日期 |
2000.08.04 |
申请人 |
AVENTIS BEHRING GMBH |
发明人 |
FEUSSNER ANNETTE;ROEMISCH JUERGEN;STOEHR HANS-ARNOLD |
分类号 |
G01N33/531;A61K38/43;A61K38/46;A61K47/02;A61K47/10;A61K47/18;A61K47/20;A61K47/22;A61K47/26;A61K47/42;A61L33/00;A61P7/02;A61P7/04;A61P9/10;A61P9/14;A61P17/02;B01D15/08;B01J20/281;C12N9/50;C12N9/64;C12N9/96;G01N30/88;(IPC1-7):C12N9/50 |
主分类号 |
G01N33/531 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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