| 摘要 |
PURPOSE: Pharmaceutical compositions are provided for the treatment of nicotine dependence or addiction, tobacco dependence or addiction, reduction of nicotine withdrawal symptoms or aiding in the cessation or lessening of tobacco use or substance abuse. CONSTITUTION: The therapeutically effective pharmaceutical combination is comprised of a nicotine receptor partial agonist and an anti-depressant or anxiolytic agent and a pharmaceutically acceptable carrier. In a more specific embodiment, the anti-depressant is selected from a tricyclic anti- depressant, a serotonin reuptake inhibitor anti-depressant (SRI), an atypical anti-depressant or a monoamine oxidase inhibitor, their pharmaceutically active salts and their optical isomers. In another more specific embodiment, the anti-depressant is selected from amitriptyline, imipramine, sertraline, paroxetine, fluoxetine, bupropion, nefazodone, phenelzine, tranylcypromine, moclobemide, venlafaxine or a pharmaceutically acceptable salt or their optical isomers thereof. A preferred antidepressant is bupropion hydrochloride or one of its optical isomers.
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