| 摘要 |
<p>A carboxyamido derivative represented by formula (I) useful as a medicament for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity: wherein R1 represents 2-hydroxybenzimidazolyl group which may be substituted and the like; Y represents oxygen atom or sulfur atom; R2 represents hydrogen atom or an alkyl group; n represents 0, 1 or 2; at least one of X?1, X2, X3, X?4 and X5¿ represent (a) NR3R4, (b) N+R5R6R7, or (c) a nitrogen-containing heterocyclic group having one or more sp2 nitrogen atoms which may be substituted, in which R?3 and R4¿ independently represent hydrogen atom, an alkyl group and the like, or R3, N and R4 may combine together to form a nitrogen-containing heterocyclic group which may be substituted; R?5, R6 and R7¿ represent an alkyl group and the like, or R5, N and R6 may combine together to form a nitrogen-containing heterocyclic group which may be substituted; or neighboring X?2 and X3 or X3 and X4¿ and the like may combine together with the benzene ring to form an isoindoline ring and the like, and the rest of them represent hydrogen atom.</p> |
