| 摘要 |
<p>Phage display technology is used to detect interactions between compounds. In one aspect, the invention features a method for determining compounds which interact with each other by providing a genetic package (GP), which comprises a compound associated with the surface of the GP and encoded within the genetic material of the GP. The GP is incapable of independently replicating in a host cell, but capable of replicating in a host cell after coinfection with a second GP. The second GP comprises another compound associated with its surface and encoded within its genetic material. The second GP is also incapable of independently replicating in a host cell, but capable of replicating after coinfection with the first GP. The first GP and the second GP are contacted with host cells under conditions such that coinfection occurs substantially only when the surface compound of the first GP interacts with the surface compound of the second GP, the GPs are allowed to replicate, and the genetic material of at least one of the GPs is then recovered.</p> |
