CARBOXYAMIDO DERIVATIVES

摘要

A carboxyamido derivative represented by formula (I) useful as a medicament for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity: wherein R<1> represents 2-hydroxybenzimidazolyl group which may be substituted and the like; Y represents oxygen atom or sulfur atom; R<2> represents hydrogen atom or an alkyl group; n represents 0, 1 or 2; at least one of X<1>, X<2>, X<3, X?4> and X<5> represent (a) NR<3>R<4>, (b) N+R<5>R<6>R<7>, or (c) a nitrogen-containing heterocyclic group having one or more sp<2> nitrogen atoms which may be substituted, in which R<3> and R<4> independently represent hydrogen atom, an alkyl group and the like, or R<3>, N and R<4> may combine together to form a nitrogen-containing heterocyclic group which may be substituted; R<5>, R<6> and R<7> represent an alkyl group and the like, or R<5>, N and R<6> may combine together to form a nitrogen-containing heterocyclic group which may be substituted; or neighboring X<2> and X<3> or X<3> and X<4> and the like may combine together with the benzene ring to form an isoindoline ring and the like, and the rest of them represent hydrogen atom.