METHOD FOR THE PREPARATION OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYCYTIDINE DERIVATIVES

摘要

The present invention is directed to a synthetic method of compound (I), more specifically, to the synthetic method of compound (1) which is cost-effective with the use of deoxyuridine derivatives as raw materials and mass-produceable with easy reaction, separation, and purification. The present invention does not only allow the large-scale snythesis with high yield due to easy reaction and purification, but also can provide the lower-priced medications against Hepatitis B virus and AIDS since the present invention is superior to and more economical than the conventional processes in terms of the costs for equipments, law-materials, and processing by using the low-cost and non-toxic reagents starting from uracil derivatives which are cheaper than cytosine derivatives.