| 摘要 |
<p>Development of selective PDE IV inhibitors excellent in antiasthmatic activity, safety, and so on. Compounds of general formula (1) or pharmaceutically acceptable salts thereof exhibit a selective PDE IV inhibiting effect and are useful as drugs, particularly antiasthmatic agent; wherein A is an optionally substituted 5- or 6-membered heteroaryl group or a fused ring thereof with benzene; B is carbon or nitrogen; R1 is hydrogen, lower alkyl, trifluoromethyl, hydroxyl, lower alkoxy, a residue of a carboxylic acid or a derivative thereof, amino, or a group bearing an amino nitrogen atom; R2 is hydrogen, halogeno, cyano, nitro, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, trifluoromethyl, hydroxyl, lower alkoxy, a residue of a carboxylic acid or a derivative thereof, amino, or a group bearing an amino nitrogen atom; and m is an integer of 1 to 8.</p> |
