| 发明名称 |
METHODS AND REAGENTS FOR REGULATING GENE EXPRESSION |
| 摘要 |
The present invention relates to a generalized approach for identifying minimal domain-specific transcriptional activation sequences. In particular, applicants have discovered that molecular diversity approaches can be used to discover minimal, co-activator domain specific synthetic activators, and that transcriptional activation can be modulated as desired at the level of co-activator recruitment.
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| 申请公布号 |
WO0118036(A3) |
申请公布日期 |
2001.06.14 |
| 申请号 |
WO2000US24010 |
申请日期 |
2000.08.31 |
| 申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER;JOSLIN DIABETES CENTER, INC. |
发明人 |
FRANGIONI, JOHN, V.;CANTLEY, LEWIS, C.;MONTMINY, MARC, R. |
| 分类号 |
A61K38/00;C07K1/04;C07K14/47;(IPC1-7):C12N15/10;G01N33/68;C12Q1/68;A61K38/04 |
主分类号 |
A61K38/00 |
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