PENICILLIN PRODUCTION USING TRANSGENIC MERODIPLOID STRAINS

摘要

The invention relates to a method for obtaining a Penicillium chrysogenum transgenic merodiploid strain in which the activity of the regulating gene controlling the biosynthesis of penicillin has been altered in a targeted manner. Hence, said strain is a hyperproductive strain of penicillin. This is the first time in which the biosynthesis of an industrially important metabolite has been increased by manipulation of a regulating gene and thereby represents an outstanding novelty in comparison with previously used technologies.