发明名称 |
SYNTHETIC PEPTIDES AND METHODS OF USE FOR AUTOIMMUNE DISEASE THERAPIES |
摘要 |
<p>The present invention is directed to polypeptides and peptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides or peptides to the mammal.</p> |
申请公布号 |
EP1105414(A2) |
申请公布日期 |
2001.06.13 |
申请号 |
EP19990937393 |
申请日期 |
1999.07.22 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
STROMINGER, JACK, L.;FRIDKIS-HARELI, MASHA |
分类号 |
C12P21/02;A61K38/00;A61K38/11;A61K38/16;A61K39/00;A61L27/22;A61P1/00;A61P3/10;A61P17/00;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P37/00;A61P37/06;C07K;C07K2/00;C07K4/00;C07K5/11;C07K7/06;C07K7/08;C07K14/00;C07K14/74;(IPC1-7):C07K7/00 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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