Arrays of glycan molecules (glycoarrays) on the surface of biochips (glycochips)and uses thereof

摘要

The present invention relates to arrays of discrete sensing elements of glycans (glycoarrays) wherein glycans are immobilized on a solid support (glycochips). Furthermore, the present invention relates to a method of producing such glycoarrays comprising immobilization of a glycan on a preferably streptaviding coated sensing surface via biotin or a derivative thereof. In addition, the present invention relates to the use of such glycoarrays for discriminating complex biological samples, diagnosing a disease which correlates with the presence or absence of glycan binding molecules as well as to methods of identifying an organism by generation of signal pattern from a biological sample, which is indicative for the presence or absence of a particular organism. Furthermore, the present invention relates to a kit comprising the glycoarray of the invention useful in diagnostic assays.