1,3,4-oxadiazoline derivatives and drugs containing these derivatives as the active ingredient

摘要

A 1,3,4-oxadiazoline derivative of formula (I) ,wherein W is oxygen, sulfer ;R is hydrogen, alkyl, CycA, etc.; AA<1> is a single bond, amino acid residue, etc.; AA<2> is a single bond, amino acid residue, etc.; R<7> and R<8> are hydrogen, alkyl, etc.; R<9> is hydrogen, alkyl, etc., and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of inflammatory diseases, diseases induced by apoptosis, diseases induced by disorders of immune responses, autoimmune diseases, diseases induced by decomposition of proteins which compose organism, shock, circulatory system disorders, blood coagulation systems disorders, malignant tumors, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitic diseases, nerve degeneration diseases, pulmonary disorders, bone resorption diseases, endocrinesthenia, etc.