发明名称 |
Semaphorin receptor |
摘要 |
The present invention provides screening methods for agonists or antagonists of Sema6C using Plexin-A1, and tools for the screening and the like. It evaluates a case of making a recombinant protein having an extracellular domain of Semaphorin 6C contact a protein having an extracellular domain of Plexin-A1 by comparing it with a case of contacting a recombinant protein and a target substance having an extracellular domain of Semaphorin 6C, or the target substance with a protein having an extracellular domain of Plexin-A1. The evaluation will be carried out by the connectivity of a protein having an extracellular domain of Semaphorin 6C, a growth cone collapse activity of Plexin-A1 expressing cell, or a contractile activity of Plexin-A1 expressing cell. <IMAGE> |
申请公布号 |
AU1551901(A) |
申请公布日期 |
2001.06.12 |
申请号 |
AU20010015519 |
申请日期 |
2000.11.27 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY CORPORATION;SUMITOMO PHARMACEUTICALS COMPANY, LIMITED |
发明人 |
HAJIME FUJISAWA;TORU KIMURA;YASUNORI MURAKAMI;KAORU KIKUCHI |
分类号 |
C12N15/00;A61K45/00;A61P25/02;A61P27/02;A61P27/16;A61P35/00;A61P43/00;C07K14/00;C07K14/47;C07K14/705;C07K14/71;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12Q1/68;G01N33/15;G01N33/50;G01N33/566;G01N33/68 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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