DRUG INDUCIBLE SYSTEM AND USE THEREOF

摘要

The present invention relates to a drug inducible vector regulatable with a transactivator native to a host, and to a transplantable autologous tissue capable of engrafting in a recipient without requiring toxic conditioning, for transgene delivery to a recipient. Current drug inducible host-vector systems are responsive to foreign non-eukaryotic transcriptional activators which are potentially immunogenic and affect the long-term suvival and function thereof. The present invention provides a drug inducible expression vector comprising a transgene operably linked to a reporter and to an inducible promoter responsive to a transcriptional activator of a host when exposed to an effective amount of a clinically acceptable drug. Such a vector may be introduced in a transplantable host derived from the recipient and capable of engrafting in the recipient without requiring toxic conditioning.