PROCESS FOR PREPARING OPTICALLY ACTIVE .ALPHA.-HYDROXY ACIDSAND DERIVATIVES THEREOF

摘要

The present invention provides a process for preparing optically active .alpha.-hydroxy acids and derivatives thereof by subjecting the alkylated 1, 3- dioxolanones of formula (IV) wherein R1 and R2 are the same or different and are each independently H or C1-6 alkyl; R5 is H, C1-16 alkyl, or unsubstitut ed or substituted phenyl; and R6 is C1-8 alkyl, C2-7 alkenyl or unsubstituted o r substituted benzyl, to either alcoholysis or hydrolysis, in which the alkylated 1,3-dioxolanones are obtained by using 10-camphorsulfonamide as a chiral auxiliary.