| 摘要 |
<p>The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R1 is H or together with R3 forms a β-epoxide or R1 is absent if there is a 5-10 or 4-5 double bond; R2 is (C¿1?-C5)alkyl or CF3; R?3¿ is βH, βCH¿3? or together with R?1¿ forms a β-epoxide or R3 is absent if there is a 5-10 double bond; R4 is H, lower alkyl; Y is [H, H], [OH, H], =O, [OH, lower alkyl], [OH, (C¿2?-C5)alkenyl], [OH, (C2-C5)alkynyl] or (C1-C6)alkylidene, whereby said alkyl, alkenyl, alkynyl and alkylidene is optionally halogenated; =NOR?5¿, whereby R5 is H, lower alkyl; dotted lines represent an optional double bond, or prodrugs thereof for the treatment of arthritic diseases and/or autoimmune diseases.</p> |
