发明名称 |
A NOVEL GENE, DISRUPTED IN SCHIZOPHRENIA |
摘要 |
A newly identified gene, DIS1 is disrupted by a (1;11)(q42.1;q14.3) translocation which segregates with schizophrenia. We have examined the genomic structure of DIS1 and found that the gene consists of 13 exons estimated to extend across at least 300kb of DNA. Exon 11 contains an alternative splice site which removes 66 nucleotides from the open reading frame. The final intron of DIS1 belongs to the rare AT-AC class of introns. 8 expressed sequence tags (ESTs) located within introns 3, 7, 9 and 10 of DIS1 have also been identified. These ESTs have not yet been assigned to DIS1 and may therefore represent further novel genes in the region.
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申请公布号 |
WO0140301(A2) |
申请公布日期 |
2001.06.07 |
申请号 |
WO2000EP11915 |
申请日期 |
2000.11.28 |
申请人 |
AKZO NOBEL N.V.;MEDICAL RESEARCH COUNCIL;UNIVERSITY OF EDINBURGH;PORTEOUS, DAVID;MILLAR, KIRSTY;BLACKWOOD, DOUGLAS |
发明人 |
PORTEOUS, DAVID;MILLAR, KIRSTY;BLACKWOOD, DOUGLAS |
分类号 |
A61K38/00;A61K48/00;C07K14/47;C12N15/12;(IPC1-7):C07K14/47 |
主分类号 |
A61K38/00 |
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