PHOSPHORYLATION OF TERMINAL PRIMARY ALCOHOL GROUPS

摘要

The invention relates to chemical processes and chemical intermediates which are useful in the selective formation of a primary mono-phosphoryl group (- OPO(OH2)) in a terminal 1,2-diol-propanoyl (HO-CH2CH(OH)-CO-) containing system, and to chemical processes and chemical intermediates (and processes for their manufacture) particularly useful for the manufacture of anti-Gram positive oxazolidinone bacterial agents containing such functionality, in particular for the preparation of 5(R)-Isoxazol-3-yloxymethyl-3-(4-(1-(2(S) - hychoxy-3-phosphoryl-propanoyl)-1,2,5,6-tetrahydropyridy-4-il)3,5- difluorophenyl)oxazolidin-2-one.