发明名称 COMBINATION OF ALDOSE REDUCTASE INHIBITORS AND ANTIHYPERTENSIVE AGENTS FOR THE TREATMENT OF DIABETIC COMPLICATIONS
摘要 This invention is directed to methods, pharmaceutical compositions and ki ts comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or said prodrug and an antihypertensive agent, a prodrug thereof or a pharmaceutically acceptable salt of said antihypertensive agent or said prodrug. This invention further relates to methods of using those pharmaceutical compositions for the treatment of diabetic complications such as diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, myocardial infarction, cataracts and diabetic cardiomyopathy.
申请公布号 CA2327575(A1) 申请公布日期 2001.06.07
申请号 CA20002327575 申请日期 2000.12.05
申请人 PFIZER PRODUCTS INC. 发明人 MYLARI, BANAVARA LAKSHMAN
分类号 C07D239/96;A61K31/13;A61K31/16;A61K31/167;A61K31/185;A61K31/198;A61K31/275;A61K31/277;A61K31/353;A61K31/4184;A61K31/4188;A61K31/426;A61K31/44;A61K31/4422;A61K31/4747;A61K31/502;A61K31/517;A61K31/538;A61K31/554;A61K45/06;A61K45/08;A61P3/10;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P13/12;A61P25/00;A61P27/02;A61P27/12;C07D277/20;C07D277/36;C07D413/06;C07D417/06;C07D487/10;C07D491/107;(IPC1-7):A61K31/502;A61K31/418;A61K31/442;A61K31/474 主分类号 C07D239/96
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