发明名称 |
PROCESS FOR PREPARING N,N,6- TRIMETHYL-2 -(4-METHYLPHENYL)- IMIDAZO- 1,2-A] -PYRIDINE-3- ACETAMIDE AND SALTS THEREOF |
摘要 |
<p>It comprises reducing the hydroxy ester of formula (X) by reacting it in DMF and then with an iminium salt of formula (XIII) formed in situ with thionyl chloride and dimethylformamide, and subsequent reduction with an appropriate reducing agent to form the ester of formula (XII), which is then reacted with dimethylamine in a polyhydroxylated solvent medium at an appropriate temperature.</p> |
申请公布号 |
EP1104765(A2) |
申请公布日期 |
2001.06.06 |
申请号 |
EP19990938403 |
申请日期 |
1999.08.04 |
申请人 |
QUIMICA SINTETICA, S.A. |
发明人 |
LABRIOLA, RAFAEL |
分类号 |
A61K31/415;A61K31/435;C07D471/04;(IPC1-7):C07D471/04 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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