| 摘要 |
A novel process is provided for the preparation of imidazolidinone alpha v beta 3/ alpha v beta 5 integrin antagonists, and the useful intermediates obtained therein. These compounds are antagonists of alpha v beta 3/ alpha v beta 5 integrin receptors and thus useful for inhibiting bone resorption and treating and preventing osteoporosis. Also disclosed is 3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]imidazolidin-1-yl}-3(S)-(6-methoxy-pyridin-3-yl)-propionic acid in the form of a hemihydrate. |
