| 摘要 |
DNA and proteins sequences are disclosed for several VIAF homologs. The VIAF sequence modulates the anti-apoptotic and signaling properties of IAP family members. The disclosure also includes specific binding agents (such as antibodies) that recognize VIAF, methods of decreasing apoptosis by increasing VIAF expression, methods of increasing apoptosis by decreasing VIAF expression, methods of treating disease caused by mutations, therapeutic compositions that include VIAF, recombinant DNA molecules, probes, and transformed cells that incorporate the DNA sequence to express VIAF. The disclosure also includes methods of diagnosis and treatment of diseases caused by an increased expression of VIAF, such as neurodegenerative diseases, and methods of treatment of diseases caused by unwanted apoptosis, such as occurs in autoimmune diseases and neurodegenerative disorders. The disclosure also includes methods of diagnosis and treatment of diseases caused by an underexpression of VIAF, such as cancer. |
