Methods for treatment of human huntington's disease and methods of screening foractive agents

摘要

Genes modulated by the expression of a mutant huntingtin protein associated with Huntington's Disease have been determined. A profile of mRNAs that are modulated has been established as neurodegeneration progresses through the disease. Levels of mRNA encoding components of neurotransmitters, calcium and retinoid signaling pathways at both early and late symptomatic disease states have been established. Methods for the treatment or amelioration of disease have been determined based on the mRNA profile determined. Further, methods for screening for agents active in ameliorating and/or preventing progression of Huntington's Disease can be determined by examining changes in the level of expression of the mRNAs and/or proteins of the Huntington's Disease profile of the present invention.