| 摘要 |
The present invention relates to the mammalian <i>fsh25</i> gene, a gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses <i>fsh25</i> nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, <i>fsh25</i> gene products and antibodies directed against such gene products, cloning vectors containing mammalian <i>fsh25</i> gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of <i>fsh25</i> genes and gene products and to using such compounds as therapeutic agents in the treatment of <i>fsh25</i>-related disorders, <i>e.g.</i>, neuropsychiatric disorders. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of <i>fsh25</i>-related disorders, <i>e.g.</i>, neuropsychiatric disorders, including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder, and to methods and compositions for the treatment of these disorders. |
