| 摘要 |
This invention relates to novel aryl substituted azabenzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof.or a pharmaceutically acceptable salt thereof whereinn is an integer from 1 to 4X is CH or N;R1 is H, (C1-C6)alkyl or (C1-C6) alkoxy;R2 is H, (C1-C6)alkyl or (C1-C6) alkoxy;each R3 is independently selected from H, (C1-C6)alkyl (C1-C6) alkyloxy, (C1-C6) alkylthio, halo, nitro, cyano, ethynyl, hydroxy and trifluoromethyl;R4 is H, (C1-C6)alkyl or (C1-C6) alkoxy;R5 is H, (C1-C6)alkyl or (C1-C6) alkyloxy, trifluoromethyl; andW is N or C;Y is N (R4), N, S or OZ is R4, NR4H, O, or OH;Provided that when Y=NR4, W=C, Z=O, there is a single bond between YW and a double bond between WZ; andwhen Y=O or S, W=C, Z=O, there is a single bond between YW and a double bond between WZ; andwhen Y=N, W=N, there is a double bond between YW and Z does not exist.when Y=N, W=C, Z=R4 or NHR4, there is a double bond between YW and a single bond between WZ; The methods of preparing these compounds and their use in the treatment of HIV, AIDS, and AIDS related diseases and in slowing the progression of HIV infection into AIDS is also disclosed.
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