发明名称 |
Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for cell differentiation induction factor action |
摘要 |
A compound represented by the formula:wherein X represents a sulfur atom or an oxygen atom; Y represents an optionally oxidized sulfur atom or an oxygen atom; Z represents a bond or a divalent hydrocarbon group; R1 represents an optionally substituted hydrocarbon group; R2 represents an optionally amidated or esterified carboxyl group; ring A represents an optionally substituted aromatic 5-membered heterocyclic ring; or a salt thereof.A compound of the above formula possesses cell differentiation inducing factor action-enhancing activity and anti-matrix metalloprotease activity and that is useful in the prevention and treatment of bone diseases such as osteoporosis, bone fractures, osteoarthritis and rheumatoid arthritis, arteriosclerosis, cancer metastasis, and diseases based on nerve degeneration.
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申请公布号 |
US6242471(B1) |
申请公布日期 |
2001.06.05 |
申请号 |
US20000559453 |
申请日期 |
2000.04.28 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
YASUMA TSUNEO;ODA TSUNEO;HAZAMA MASATOSHI;TAKETOMI SHIGEHISA |
分类号 |
C07D495/04;C07D498/04;C07D513/04;C07F9/6561;(IPC1-7):A61K31/424 |
主分类号 |
C07D495/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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