| 摘要 |
The invention relates to beta-defensins of the formula Z<1>-RCIGLXHKIGTC-Z<2>, wherein< > X = F or R and Z<1> and Z<2> are equal to each other or different from one another, Z<1> represents a substituted or unsubstituted amino acid residue, having at least one additional cysteine, Z<2> represents either a peptide residue of up to 20 amino acids, having at least two immediately adjacent cysteines or a carboxyl group or derivatized carboxyl group. The novel defensins can be used as antibiotic medicaments. |
