发明名称 |
Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
摘要 |
The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a pyrazolo[5,4-d]pyrimidine or by a 7-deazapurine purine analogue. Reduced self-aggregation and reduced fluorescence quenching are obtained when the oligomers are used in various methods involving hybridization. Methods of synthesis, as well as novel synthetic precursors, are also provided. |
申请公布号 |
AU1798901(A) |
申请公布日期 |
2001.06.04 |
申请号 |
AU20010017989 |
申请日期 |
2000.11.21 |
申请人 |
EPOCH BIOSCIENCES, INC. |
发明人 |
ALEXANDER A GALL;IGOR V KUTYAVIN;NICOLAAS M. J. VERMEULEN;ROBERT O DEMPCY |
分类号 |
G01N33/53;A61K31/519;A61K48/00;C07D487/04;C07H21/00;C07H21/04;C07K5/06;C07K5/078;C07K14/00;C12M1/00;C12N15/09;C12Q1/68;G01N33/50;G01N33/58 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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