发明名称 NOVEL SULFONYLOXAZOLAMINES
摘要 The invention relates to compounds of the general formula (I), wherein R1 an d R2 independently of one another represent H, -R6, C3-C8-cycloalkyl, -(CH2)n- R7, -(CH2)n-O-R6, -(CH2)n-NH2, -(CH2)n-NHR6, -(CH2)-N(R6)2, C2-C6-alkenyl or optionally together form a mononuclear saturated heterocycle with one or two nitrogen, oxygen and/or sulphur atoms; R3 and R4 independently of one anothe r represent H, -R6, -CF3, -NO2, -Hal, -OH, -O-R6, -NH2, -NH-R6, or -N(R6)2; R5 represents a 5- or 6-member, saturated or unsaturated heterocycle with one o r two nitrogen, oxygen and/or sulphur atoms, which is optionally monosubstitut ed or disubstituted by -R6, -CF3, -NO2, -Hal, -OH, -O-R6, -NH2, -NH-R6, or - N(R6)2; and R6 represents C1-C6-alkyl; R7 together with R3 and/or R4 represents substituted phenyl, n represents 0 to 2. The invention also relat es to the physiologically safe salts or solvates of said compounds and to the u se of the compounds of the general formula (I) as medicaments.
申请公布号 CA2389679(A1) 申请公布日期 2001.05.31
申请号 CA20002389679 申请日期 2000.11.24
申请人 MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG 发明人 GERICKE, ROLF;BOTTCHER, HENNING;GASSEN, MICHAEL;GREINER, HARTMUT
分类号 C07D263/48;A61K31/421;A61K31/422;A61K31/4439;A61K31/496;A61P1/00;A61P1/04;A61P9/00;A61P21/00;A61P25/00;A61P25/06;A61P25/08;A61P25/14;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/36;A61P29/00;A61P41/00;C07D213/81;C07D213/82;C07D307/68;C07D333/38;C07D413/04;(IPC1-7):C07D413/04 主分类号 C07D263/48
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