NOVEL INTERMEDIATE FOR SWEETENER WITH HIGH SWEETNESS AND PROCESS FOR PRODUCING THE SAME

摘要

3-(3-Hydroxy-4-methoxyphenyl)-3-methylbutyric acid can be obtained by substituting the substituent at the 3-position of the benzene ring of a butyric acid derivative which can be easily and efficiently produced by reacting a hydroxyl-protected 2-methoxyphenol, wherein the hydroxyl group of 2-methoxyphenol is protected in the form of a sulfonate, with 3-methylcrotonic acid in the presence of an acid. By further converting the carboxyl group into a formyl group, 3-(3-hydroxy-4-methoxyphenyl)-3-methyl butyl aldehyde can be easily produced. This aldehyde derivative can be easily derived into a compound, which is excellent as a sweetener with a high sweetness, by reductive alkylation with Aspartame.