| 摘要 |
A polypeptide is identified as being functionally included in a signal transduction pathway having a biological effect. Contemplated polypeptides a re different from a retinoic acid receptor, a retinoid X receptor, or a cellula r retinoic acid binding protein, however, binding of the retinoid or retinoid metabolite lead to a modulation of the biological effect. In particularly contemplated methods, a retinoid or retinoid metabolite is administered to a cell or mammal in a concentration effective to modulate the biological effec t.
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