CATALYTIC RNAS WITH AMINOACYLATION ACTIVITY

摘要

The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylati on activity comprise a catalytic domain and an aminoacylation domain. The catalytic RNA molecules having trans aminoacylation activity only have the catalytic domain. A method is provided for constructing and screening of the se molecules. These molecules are suitable for aminoacylating tRNA-like molecul es with specific amino acids.