CHIMERIC GENE ENABLING EXPRESSION OF THE GENE OR CDNA OF TYPE I INSULIN-LIKE GROWTH FACTOR (IGF-I) IN THE PANCREAS AND UTILIZATION THEREOF IN GENIC THERAPY OF DIABETES MELLITUS

摘要

The invention relates to a chimeric gene using the gene or cDNA of type I insulin-like growth factor (IGF-I) directed by a promoter or promoter fusion enabling regulated expression of IGF-I in the pancreas. The invention also relates to an expression vector enabling the expression of IGF-I in the pancreas. The invention further relates to a pancreatic cell expressing said chimeric gene. The invention additionally relates to the utilization of said chimeric gene or said expression vector in the development of therapeutic application for diabetes mellitus.