The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylation activity comprise a catalytic domain and an aminoacylation domain. The catalytic RNA molecules having trans aminoacylation activity only have the catalytic domain. A method is provided for constructing and screening of these molecules. These molecules are suitable for aminoacylating tRNA-like molecules with specific amino acids.
申请公布号
WO0138582(A1)
申请公布日期
2001.05.31
申请号
WO2000US32184
申请日期
2000.11.22
申请人
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人
HIROAKI, SUGA;DIMITRIOS, KOUROUKLIS;HIROHIDE, SAITO;LEE, NICK;BONZAGNI, NEIL